JULIA HENDRIX MIWA

Department of Chemistry

Wellesley College

EDUCATION

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, 1987-1992.

Ph.D. in Chemistry, June, 1992. Thesis title: Synthesis and Conformational Studies of the b-Amyloid Protein of Alzheimer's Disease.

HAVERFORD COLLEGE, Haverford, PA, 1981-1985.

B. A., May, 1985. Graduated magna cum laude with High Honors in Chemistry.

Senior Research Project: Determination of exchange rate constants using two-dimensional NMR spectroscopy.

RESEARCH EXPERIENCE

Associate Professor: Department of Chemistry, Wellesley College (2002 - present)

Assistant Professor (1994-2002)

Synthesis and Conformational Studies of Peptide Analogs with Backbone Modifications: Perform automated and manual solid-phase peptide synthesis using Fmoc and t-Boc protection schemes. Analyze peptides by 2D-NMR and CD spectroscopy. Developed improved deprotection scheme for thioxo peptides.

Visiting Scientist: Whitehead Institute for Biomedical Research (June 1997 - June 2001)

Laboratory of Dr. Peter S. Kim. Synthesis and Evaluation of Thioxo Peptide Analogs of the GCN4 Leucine Zipper Helix: Prepared four thioxo peptide analogs of the GCN4 helix and analyzed their structures by analytical ultracentrifugation and CD spectroscopy.

NIH Postdoctoral Fellow: University of California, Berkeley (July 1992 - June 1994)

Laboratory of Professor Paul A. Bartlett. Design, synthesis, and evaluation of cyclic hemiketals as inhibitors of HIV&endash;1 protease. Synthesis of a combinatorial library of peptide-phosphinate inhibitors of thermolysin.

Graduate Research Fellow: Massachusetts Institute of Technology (Sept. 1987 - June 1992)

Laboratory of Professor Peter T. Lansbury, Jr. Synthesis and Conformational Studies of the b-Amyloid Protein of Alzheimer's Disease: Carried out the solid-phase synthesis of the b-amyloid protein via a fragment-coupling approach.

TEACHING EXPERIENCE

Department of Chemistry, Wellesley College, 1994-present. Teaching responsibilities have included organic and introductory chemistry, seminars on bioorganic chemistry and combinatorial chemistry, and supervision of the senior honors colloquium.

Lecturer: Department of Chemistry, University of California, Berkeley, 1993. Supervised all teaching assistants for Organic Chemistry II (chemistry majors course). Replaced lecturing professor on several occasions and led weekly review sessions throughout the semester.

Teaching Assistant: Dept. of Chemistry, Massachusetts Institute of Technology, 1987-88. Taught advanced integrated laboratory course (semester 1) and Organic Chemistry I (semester 2)

Science Teacher: Teaneck High School, Teaneck, NJ, 1985-1987. Taught chemistry and physics. Coached varsity swimming and freshman softball.

HONORS AND AWARDS

Pinanski Prize for Excellence in Teaching, Wellesley College, June 1997.

Camille and Henry Dreyfus Faculty Start-up Grant for Undergraduate Institutions

National Institutes of Health Postdoctoral Fellowship, awarded June 1992.

Sigma Xi, Massachusetts Institute of Technology, elected 1991.

Chemistry Outreach Fellowship, Massachusetts Institute of Technology, 1990-1991.

Whitaker Research Fellowship, Massachusetts Institute of Technology, 1988-1990.

DuPont Scholar, Massachusetts Institute of Technology, September 1987.

Geraldine R. Dodge Teaching Fellowship, August, 1985. Awarded to the fifteen most outstanding teachers in New Jersey's Alternate Route to Certification program.

PROFESSIONAL ASSOCIATIONS

American Chemical Society Councilor, Northeastern Section

Member, Division of Organic Chemistry

Member, Division of Chemical Education

American Association for the Advancement of Science

Sigma Xi

Phi Beta Kappa

Project Kaleidoscope, Faculty for the 21st Century

PUBLICATIONS

(Publications prior to 1993 under the name Julia Carroll Hendrix)

Miwa, J. H.; Pallivathucal, L.; Gowda, S.; Lee, K. E. “Conformational Stability of Helical Peptides Containing a Thioamide Linkage” Organic Lett., 2002; 4; 4655-4657.

Miwa, J. H.; Patel, A. K.*; Vivatrat, N.*; Popek, S. M.*; Meyer, A. M.* "Compatibility of the Thioamide Functional Group with b-Sheet Secondary Structure: Incorporation of a Thioamide Linkage into a b-Hairpin Peptide" Organic Lett. 2001, 3, 3373.

Miwa, J. H.; Margarida, L. A.*; Meyer, A. M.* "Improved Acidolytic Deprotection Conditions for the Fmoc-based Solid-Phase Synthesis of Thioxo Peptides" Tetrahedron Lett. 2001, 42, 7189.

Hendrix, J. C.; Halverson, K. J.; Lansbury, P. T., "A Convergent Synthesis of the Amyloid Protein of Alzheimer's Disease" Jr. J. Am. Chem. Soc. 1993, 114, 7930.

Hendrix, J. C.; Lansbury, P. T., Jr. "Synthesis of a Protected Peptide Corresponding to Residues 1-25 of the b-Amyloid Protein of Alzheimer's Disease" J. Org. Chem. 1992, 57, 3421.

Hendrix, J. C.; Jarrett, J. T.; Anisfeld, S. T.; Lansbury, P. T., Jr. "Studies Related to a Convergent Fragment-Coupling Approach to Peptide Synthesis Using the Kaiser Oxime Resin" J. Org. Chem. 1992, 57, 3414.

Hendrix, J. C.; Lansbury, P. T., Jr. "Synthetic Approaches to Amyloid-Forming and Transmembrane Proteins" IN: Peptides: Chemistry and Biology; Twelfth American Peptide Symposium. Smith, J. A. and J. E. Rivier (Ed.). Escom Science Publishers B.V.: Leiden, Netherlands, 1991, p. 129.

Hendrix, J. C.; Halverson, K. J.; Jarrett, J. T.; Lansbury, P. T., Jr. "A Novel Solvent System for Solid Phase Peptide Synthesis: The Disaggregation of Resin-Bound Antiparallel b-Sheet has Practical Consequences" J. Org. Chem. 1990, 55, 4517.

Lansbury, P. T., Jr.; Hendrix, J. C.; Coffman, A. I. "A Practical Method for the Preparation of Protected Peptide Fragments Using the Kaiser Oxime Resin" Tetrahedron Lett. 1989, 30, 4915.

 

PAPERS PRESENTED AT PROFESSIONAL MEETINGS AND COLLOQUIA

* denotes Wellesley College undergraduate

** denotes Harvard College undergraduate

* Julia Miwa jmiwa@wellesley.edu
* Dept. of Chemistry
* Date Created: Aug. 23, 2004
* Last Modified: Aug.23, 2004
* Expires: August 31, 2005