Presentation Outline
Specific Aims
•

Demonstrate that MRI can be used in conjunction with contrast agents to provide quantitative information about the distribution of macromolecules in the normal rabbit eye
••
Using contrast-enhanced MRI, determine if acute anterior uveitis produces a long-term alteration in the blood aqueous barrier (BAB) permeability
• Compare the permeability properties of untreated uveitic eyes with those treated using anti-inflammatory agents
Looking into the Eye with MRI
Research Collaborators
Student Faculty Research
History of MRI
Principles of MRI
MR Image of Rabbit Eye
Specific Aims
MR Imaging Studies: Specific Aim 1
Contrast-enhanced MRI of Normal Rabbit Eye
Typical Magnevist MRI Results
MR Imaging Studies: Specific Aim 2
What is Anterior Uveitis
MR Imaging Studies: Specific Aim 3
MR Image Regions Selected for Intensity Measurement
Magnevist Flow into Anterior Chamber of Control Rabbit
Magnevist Flow into Anterior Chamber of Treated Rabbit
Magnevist Flow into Ciliary Process of Control Rabbit
Magnevist Flow into Ciliary Process of Treated Rabbit
Summary of Results
Conclusions
Acknowledgements

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  Susan D. Kunk
 Nancy H. Kolodny
 June 25, 2001
 June 25, 2001