Wellesley College
106 Central Street
Wellesley, MA 02481

781.283.3081
jchadwic@wellesley.edu

Education:
Bachelor of Arts
Wheaton College (MA), '05
Major: Psychobiology, American History

Current Interests:
Our lab is interested in how steroid hormones and their receptors affect gene expression in the rat brain and thus influence reproductive behavior. My work focuses on protein-protein interactions between steroid receptors and their co-regulators, proteins that facilitate or repress the expression of target genes. I am currently working to generate a Co-Immunoprecipitation (Co-IP) assay that will let us examine protein-protein interactions between nuclear steroid receptors and their co-regulators in brain. Additionally, I am using triple label fluorescent immunohistochemistry to investigate the expression of estrogen induced progesterone receptor and coactivators in the female mouse brain. Part of my job involves helping students on their research, which I enjoy very much.

Previous  Research:
While at Wheaton College, my research focused on the conservation of endangered species. Specifically, I worked on projects studying the Northern Diamondback Terrapin (Malaclemys terrapin) and on one project studying an endangered population of Fishers (Martes pennanti) in California. While studying the Terrapins on Cape Cod, I took part in a twenty year population study, protected Terrapin nests from predators, and conducted research on juvenile Terrapin use of salt marshes. During my junior and senior years I was in charge of a Terrapin headstart program at Wheaton College. During this time we raised and released to the wild approximately 85 Terrapin hatchlings that otherwise would not have survived.

Future  Research:
I was recently accepted to the Organismic & Evolutionary Biology program at UMass Amherst, where I will pursue my PhD in Dr. Stephen McCormick's lab. Dr. McCormick's lab studies osmoregulation in Atlantic Salmon and other anadromous fishes. I hope to investigate the effects of endocrine disrupters and stress on growth and osmoregulation in Atlantic Salmon.

REFERENCES

Publications:
Molenda-Figueira, H.A, Murphy, S.D., Shea, K.L., Siegal, N.K., Zhao, Y., Chadwick, J.G., Denner, L.A. and Tetel, M.J. Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes. Endocrinology, In press.

Abstracts:
Im, D., Yore, M.A., Chadwick, J.G., Tetel, M.J. Steroid receptor coactivator-2 (SRC-2) from rat brain interacts differently with estrogen receptor and progesterone receptor subtypes. The Endocrine Society, 2008.

Yore, M.A., Im, D., Chadwick, J.G., Tetel, M.J. Steroid receptor coactivator-2 (SRC-2) from female rat hypothalamus and hippocampus interacts differently with the progestin receptor isoforms. Society for Neuroscience, 2007.

Tetel, M.J., Molenda, H.A., Yore, M.A., Im, D., Chadwick, J.G., Steroid hormone action: From the test tube to the brain. International Congress of Neuroethology, Vancouver, Canada, 2007.

Tetel, M.J., Yore, M.A., Webb, L.K., Chadwick, J.G., Molenda-Figueira, H.A. Steroid receptor coactivator-2 is expressed in female rat brain and physically interacts with estrogen receptor (ER)α, but not ERβ, in a ligand dependent manner. Society for Neuroscience, 258.9, 2006.

Brennessel, B., Chadwick, J., Stewart-Swift, C., Warren, N. The importance of the salt marsh as a nursery for Diamondback terrapins. The State of the Harbor Conference, Wellfleet, Massachusetts, 2003.