Publications

Publications (Wellesley College undergraduate authors are underlined.)

  1. Norman, N.; Bao, S.; Curts, L.; Hui, T.; Zheng, S. L.; Shou, T.; Zeghibe, A.; Burdick, I.; Fuehrer, H.; and Huang, A. “Highly Selective N-Alkylation of Pyrazoles: Crystal Structure Evidence for Attractive Interactions.” J. Org. Chem.  2022, 87, 10018-10025.
  2. Huang, A.; Wo, K.; Lee, S.; Kneitschel, N.; Chang, J.; Zhu, K.; Mello, T.; Bancroft, L.; Norman, N.; Zheng, S. L. “Regioselective Synthesis, NMR, and Crystallographic Analysis of N1-Substituted Pyrazoles.” J. Org. Chem. 2017, 82, 8864-8872
  3. Huang, A.; Wo, K.; Pierson, A.; Lee, S.; Yang, E.; Johnson, C. “5-Hydroxyl Hydantoins via One-Pot Microwave-Assisted Air Oxidation of Ugi Products.” J. Heterocycl. Chem. 2016, 53(5), 1499-1504.
  4. Xing L. and Huang, A. “Bruton's TK inhibitors: structural insights and evolution of clinical candidates.” Future Med. Chem. 2014, 6(6), 675–695.
  5. Kaila, N.; Follows, B.; Leung, L.; Thomason, J.;  Huang, A.; Moretto, A.; Janz, K.; Lowe, M.; Thomason, J.; Mansour, T.; Hubeau, C.; Page, K.; Morgan, P.; Fish, S.; Xu, X.; Williams, C.; and Saiah, E. “Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases.” J. Med. Chem. 2014, 57 (4), 1299-1322.
  6. Kaila, N.; Huang, A.; Moretto, A.; Follows, B.; Janz, K.; Lowe, M.; Thomason, J.; Mansour, T.; Hubeau, C.; Page, K.; Morgan, P.; Fish, S.; Xu, X.; Williams, C.; and Saiah, E. “Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases” J. Med. Chem. 2012, 55(11), 5088-5109.
  7. Mark Schnute, Adrian Huang, and Eddine Saiah. “Bruton’s Tyrosine Kinase (BTK)”, in Anti-Inflammatory Drug Discovery. Edited by J. I. Levin and S. Laufer.  Royal Society of Chemistry Royal Society of Chemistry: Cambridge, UK, 2012; Chapter 10, pp 297-322.
  8. Huang, A.; Moretto, A.; Janz, K.; Lowe, M.; Bedard, P.W.; Tam, S.; Di, L.; Clerin, V.; Sushkov, N.; Tchemychev, B.; Tsao, D. H. H.;  Keith Jr., J. C.; Shaw, G.; Schaub, R. G.; Wang, Q.; Kaila, N. “Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury” J. Med. Chem. 2010, 53(16), 6003-6017.
  9. Huang, A.; Li, H. Q.; Massefski, W.; Saiah, E. “Direct Trifluoromethylation of Nitriles Promoted by Tetrabutylammonium Bifluoride.” Synlett, 2009, 15, 2518-2520.
  10. Wu, J.J.; Green, N.; Hotchandani, R.; Hu, Y., Condon, J.; Huang, A.; Kaila, N.; Li, H. Q.; Guler, S.; Li, W.; Tam, S.; Wang, Q.; Pelker, J.; Marusic, S.; Hus, S.; Hall, J. P.; Telliez, J. B.; Cui, J.; Li, L.L. “Selective Inhibitors of Tumor Progression Loci-2 (Tpl2) Kinase with Potent Inhibition of TNF-a Production in Human Whole Blood.” Bioorg. Med. Chem. Lett. 2009, 19(13), 3485-3488.
  11. Huang, A.; Joseph-McCarthy, D.; Lovering, F.; Sun, L.; Wang, W.; Xu, W.; Zhu, Y.; Cui, J.; Zhang, Y.; Levin, J. “Structure-based design of TACE selective inhibitors: Manipulations in the S1'-S3' pocket.” Bioorg. Med. Chem. 2007, 15(18), 6170-6181.
  12. Green, N.; Hu, Y.; Janz, K.; Li, H.; Kaila, N.; Guler, S.; Thomason, J.; Joseph-McCarthy, D.; Tam, S.; Hotchandani, R.; Huang, A.; Wang, Q.; Leung, L.; Pelker, J.; Marusic, S.; Hsu, S.; Telliez, J.; Hall, P.; Cuozzo, J.; Lin, L. “Inhibitors of Tpl2 Kinase and TNF-a Production: Selectivity and In Vivo Anti-inflammatory Activity of Novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.” J. Med. Chem. 2007, 50(19), 4728-4745.
  13. Kaila, N.; Janz, K.; Huang, A.; Moretto, A.; DeBernardo, S.; Bedard, P.W.; Tam, S.; Clerin, V.; Keith Jr.; J. C.; Tsao, D. H. H.; Sushkova, N.; Shaw, G.; Camphausen, R. T.; Schaub, R. G.; Wang, Q. “2-(4-Chlorobenzyl)-3-Hydroxy-7,8,9,10-Tetrahydrobenzo[H]Quinoline-4-Carboxylic Acid (PSI-697): Identification Of A Clinical Candidate From The Quinoline Salicylic Acid Series Of P-Selectin Antagonists.” J. Med. Chem. 2007, 50(1), 40-64.
  14. Lombart, H.; Feyfant, E.; Joseph-McCarthy, D.; Huang, A.; Lovering, F.; Sun, L.; Zhu, Y.; Zeng, C.; Zhang, Y.; Levin, J. “Design and Synthesis of 3,3-Piperidine Hydroxamate Analogs as Selective TACE Inhibitors.”  Bioorg. Med. Chem. Lett. 2007, 17, 4333-4337.
  15. Joseph-McCarthy, D.; Parris, K.; Huang, A.; Failli, A.; Quagliato, D.; Dushin, E. G.; Novikova, E.; Severina, E.; Tuckman, M.; Petersen, P. J.; Dean, C.; Fritz, C. C.; Meshulam, T.; DeCenzo, M.; Dick, L.; McFadyen, I. J.; Somers, W. S.; Lovering, F.; Gilbert, A. M.  “Use of Structure-Based Drug Design Approaches to Obtain Novel Anthranilic Acid Acyl Carrier Protein Synthase Inhibitors.” J. Med. Chem., 2005, 48(25), 7960-7969.   
  16. Jung, M. E.; Huang, A.; Johnson, T.  “Unusual Diastereoselectivity in Intramolecular Diels-Alder Reactions of Substituted 3, 5-Hexadienyl Acrylates.  Preference for a Boat-like Structure of the Six-Atom Tether due to Ester Overlap.” Org. Lett. 2000, 2(13), 1835-1837.
  17. Jung, M. E.; Huang A. “Use of Optically Active Imidazolidines in Asymmetric Induction.” Org. Lett. 2000, 2(17), 2659-2661.
  18. Fleming, F.; Huang, A.; Sharuef, V.; Pu, Y. “Unsaturated nitriles: Procedures for a Domino Ozonolysis-Aldol Syntheses of Oxonitriles.” J. Org. Chem., 1999, 64, 2830.
  19. Huang, A.; Marcone, J.; Mason, K.; Marshall, W.; Moloy, K. “N-Pyrrolyl Phosphines: Enhanced π-Acceptor Character via Carboalkoxy-Substitution.” Organometallics, 1997, 16, 3377-3380.
  20. Fleming, F.; Huang, A.; Sharief, V.; Pu, Y. “Unsaturated Nitriles: A Domino Ozonolysis-Aldol Syntheses of Highly Reactive Oxonitriles.” J. Org. Chem. 1997, 62, 3036-3037.