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The nuclear receptor coactivator, SRC-1, from rat brain physically interacts with estrogen receptor (ERα and ERβ) when bound to estradiol (E2, lanes 2 & 5) but not in the absence of hormone (lanes 3 & 6) or in the presence of the estrogen receptor antagonist, Tamoxifen (TX, lanes 4 & 7). (Molenda-Figueira et al., 2008) |