src-1 from brain associates with er(alpha) and er(beta) in a legand-dependent manner

The nuclear receptor coactivator, SRC-1, from rat brain physically interacts with estrogen receptor (ERα and ERβ) when bound to estradiol (E2, lanes 2 & 5) but not in the absence of hormone (lanes 3 & 6) or in the presence of the estrogen receptor antagonist, Tamoxifen (TX, lanes 4 & 7). (Molenda-Figueira et al., 2008)